General Information on Meldonium

It is a structural synthetic analogue of gamma-butyrobetaine, a precursor of carnitine. It inhibits the enzyme gamma-butyrobetaine hydroxylase, reduces the synthesis of carnitine and transport of long-chain fatty acids through cell membranes, prevents the accumulation of activated forms of unoxidized fatty acids in cells (including acylcarnitine blocking the delivery of ATP to the cell organelles). Improves metabolic processes. When ischemia prevents the violation of transport of ATP and activates glycolysis. As a result of a decrease in the synthesis of carnitine, the content of gamma-butyrobetaine, which has a vasodilating effect, increases. With acute myocardial infarction slows down tissue necrosis, shortens the rehabilitation period. On the background of heart failure improves myocardial contractility, increases tolerance to physical activity. In acute and chronic disorders of cerebral circulation promotes redistribution of blood flow to ischemic areas, thereby improving blood circulation in the source of ischemia. Increases cellular and humoral immunity. Eliminates the syndrome of withdrawal from chronic alcoholism. Increases working capacity, reduces symptoms of mental and physical overstrain, contributes to increased endurance.

Meldonium 250/500 mg

When ingested well absorbed from the digestive tract. Bioavailability is about 78%. Cmax is achieved in 1-2 hours. Biotransformed in the body with the formation of two major metabolites, which are excreted by the kidneys. T1 / 2 – 3-6 hours.

Application of the substance Meldonium:

40 caps – Meldonium 250/500 mg

60 caps – Meldonium 250/500 mg

90 caps – Meldonium 250/500 mg

120 caps – Meldonium 250/500 mg

180 caps – Meldonium 250/500 mg

360 caps – Meldonium 250/500 mg

You can buy the given dose of the drug (ORDER) right now.

Reduced performance; physical overvoltage, incl. athletes; Postoperative period to accelerate rehabilitation. In the complex therapy – IHD (angina pectoris, myocardial infarction), chronic heart failure, cardialgia against dyshormonal myocardial dystrophy, acute and chronic disorders of cerebral circulation (stroke, cerebrovascular insufficiency). An abstinence syndrome with chronic alcoholism (in combination with a specific therapy). In ophthalmology – hemophthalmia and hemorrhage into the retina of various etiologies, thrombosis of the central vein of the retina and its branches, retinopathy of various etiologies (diabetic, hypertonic) – only for parabulbar injection.

Contraindications:

Hypersensitivity, increased intracranial pressure (with violation of venous outflow, intracranial tumors).

Restrictions on the use:

Pregnancy, lactation, children under 18 (capsules, solution for injection) or 12 years (syrup), since safety and efficacy of the application are not determined.

Application in pregnancy and lactation:

Not recommended in pregnancy (safety of use is not proven). At the time of treatment, breastfeeding should be discontinued (it is not known whether it penetrates into breast milk).

Side effects of the substance Meldonium:

Dyspepsia, agitation, tachycardia, arterial hypotension, pruritus.

Interaction:

Caution should be exercised when combined with nitroglycerin, nifedipine, alpha-adrenoblockers and other antihypertensive agents and peripheral vasodilators. Compatible with antianginal drugs, anticoagulants and antiaggregants, antiarrhythmics, bronchodilators, diuretics.

To make a purchase:

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Information about the preparation Meldonium – where to find online?

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